Further, the latest INTERSALT study, and that recorded a confident association involving the urinary Na + /K + proportion and you will blood circulation pressure reported a loss of mathematical importance of this new correlation from inside the forty two of your 52 locations immediately after improvement for covariates and additionally years, sex and you can Bmi [thirty two, 33]
At present there is conflicting evidence regarding the potential blood pressure lowering effects of a reduction in urinary Na + /K + excretion. The TAIM randomized control trial in hypertensive participants on a pharmacological intervention reported no significant difference in DBP between the control diet group and a low Na + /high K + diet group during a six month period . Despite several prior studies reporting an association between blood pressure and the urinary Na + /K + ratio there are several limitations to be considered. conducted in hypertensive participants reported a significant reduction in SBP following 4 weeks of modified low sodium high potassium salt intake compared to participants receiving a normal salt intake , yet all participants were receiving a beta blocker, which is not standard first line treatment for hypertension . In addition, a cross-sectional study, the Dallas heart study, which reported an increase in SBP for an increase in the urinary Na + /K + ratio is limited by the modest correlation the use of single morning urine sample . The PURE study reported a strong linear association between estimated Na + /K + ratio and SBP, that was maintained after covariate adjustment, with the greatest SBP observed with the highest estimated K + and lowest estimated K + excretion . Although we observed that a daily K + excretion of <1 g/day is associated with elevated SBP we observed no association between the urinary Na + /K + excretion ratio and SBP at screening or following DASH-dietary intervention in SS or SR participants. In conjunction with the study by Zanetti et al. , our data suggest high Na + and low K + excretion may increase the likelihood of having increased SBP. However, the lack of association between urinary Na + /K + ratio and SBP in our data do not support a urinary Na + /K + molar excretion ratio of 1:1 as a mechanism to lower blood pressure [16, 17].
The present day study has numerous benefits: (1) This new Dashboard -Salt demo are a carefully managed feeding research and you may conformity are continuously monitored, (2) The new crossover build to own Na + input allowed participant’s in order to act as their own handle and you can reduced inter-people variability, (3) 24-h ambulatory blood pressure levels recordings have been taken, (4) lack of the latest confounding negative effects of antihypertensive mediations, and you can (5) 24-h urine test range. The major limit of your own present data ‘s the seemingly modest try dimensions that will has decreased all of our analytical capacity to discover small effects of urinary Na + , K + , and you may Na + :K + proportion toward SBP. As we failed to observe an instability for the standard features, residual confounding within our data can be done.
An excellent multicenter analysis from the Suppa ainsi que al
To summarize the modern study of your own Dash–Salt Demo suggests that weight reduction K + supplementation is not with the straight down SBP and that new decreases into https://datingranking.net/ the SBP observed following the Dashboard dietary input happened separately away from good reduction of the brand new urinary Na + /K + removal ratio no matter what brand new salt sensitivity from hypertension. All of our research don’t support the establishment regarding a-1:step 1 molar removal proportion away from Na + /K + once the blood pressure levels reducing means into the United states African american and low-African People in the us and contain the DRI recommendation not to recommend everyday K + consumption recommendations. Considering the limitations of the current study and also the constant controversy regarding your part from weight reduction K + towards the blood circulation pressure future carefully regulated scientific studies are needed to clarify the possibility effect out-of fat loss K + and you may urinary Na + /K + removal proportion toward blood pressure levels in both hypertensive and you can normotensive SS and you will SR members.
Study were examined because of the three-means ANOVA having pairwise analysis followed closely by Tukey’s post hoc sample
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